Comprehensive Hormone Plus Profile (E1, E2, E3, Pg, T, DHEA, Cortisol x4)


The Comprehensive Plus Profile expands on the Comprehensive Profile and includes estrone (E1), estriol (E3), and the Estrogen Quotient (EQ). Henry Lemon MD developed the Estrogen Quotient, a simple ratio of the cancer protective E3 relative to the proliferative estrogens E1 and E2, to assess breast cancer risk. A lower number (<1.0) indicates increased risk, and a higher number (>1.0) signifies lower risk.

Dr. Lemon stated that for maximum protection, an optimal EQ is >1.5. This information may be extrapolated to provide information on other estrogen driven disorders. Because the research on the EQ focused on women, no reference range has been established for males, however some health care providers appreciate the information the additional estrogens provide in relation to prostate health.

Comprehensive Hormone Plus Profile_Sample report.

SKU: DDI 203 Category:


Useful for:

  • Research indicates this profile could be considered for those with increased risk of developing breast cancer, or history of breast cancer or other hormonally sensitive cancers
  • Personal or family history of autoimmune disease
  • PCOS

The Comprehensive Plus Hormone Profile reports hormone levels and also calculates two important ratios. The Estrogen Quotient is a simple ratio of the cancer protective E3 relative to the proliferative estrogens E1 and E2, to assess breast cancer risk. The Pg/E2 ratio assesses the relationship between estradiol, which can drive cellular proliferation, and progesterone, which mitigates that growth and potentiates cellular differentiation.

Hormones are powerful molecules essential for maintaining physical and mental health. We frequently think of estrogen as being a female hormone, and testosterone as being a male hormone. But men AND women make both, plus several more that need to be in balance for optimum health. An imbalance of any one hormone can throw your physical and mental health out of balance, causing aggravating and even serious health problems.

One size does not fit all when it comes to hormones. For decades western medicine has prescribed hormone replacement therapy as if everyone needed the same thing and the same amount. Nothing could be further from the truth. Your hormones are like your fingerprints and in order to achieve optimal health, you need to know what your specific imbalances are. Female and male hormone tests can help identify these imbalances.

There are several ways to test for hormones (saliva, serum and urine). Saliva is the best method to test the active/bioavailable portion of hormones, which are reflective of tissue levels. If your patient is seeking bio-identical hormone replacement (BHRT), you’ll need to know active hormone levels. In addition, if using a topical (transdermal) hormone preparation for treatment, saliva testing is the most accurate tool to measure and monitor hormone status.